Supplementary Table 10

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Supplementary Table 10: Differential abundance of species across clinical outcome groups.

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Formula = Abundance ~ “OUT_GROUP”+“BIL_INC_ATB”,“PAT_AGE”+ “IMC”+ “CERCLAGE”+“RCIU”+“DIABET_GESTA”+ “HTA_PRE_ECLAM”+(1|PatientID)
OUT_GROUP: study outcome group(A-D); BIL_INC_ATB: antibiotic exposure during pregnancy; PAT_AGE: maternal age; IMC: body mass index; CERCLAGE: cervical cerclage; RCIU intrauterine growth restriction; DIABET_GESTA gestational diabetes; HTA_PRE_ECLAM: hypertensive disorders of pregnancy including pre-eclampsia.
model = LMCLR

Supplementary Table 11

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Supplementary Table 11: Differential abundance of Antibiotic Resistance Genes (ARGs) across clinical outcome groups.

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Formula = Abundance ~ “OUT_GROUP”+“BIL_INC_ATB”,“PAT_AGE”+ “IMC”+ “CERCLAGE”+“RCIU”+“DIABET_GESTA”+ “HTA_PRE_ECLAM”+(1|PatientID)
OUT_GROUP: study outcome group(A-D); BIL_INC_ATB: antibiotic exposure during pregnancy; PAT_AGE: maternal age; IMC: body mass index; CERCLAGE: cervical cerclage; RCIU intrauterine growth restriction; DIABET_GESTA gestational diabetes; HTA_PRE_ECLAM: hypertensive disorders of pregnancy including pre-eclampsia.
model = CPLM

Supplementary Table 12

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Supplementary Table 12: Differential abundance of Antibiotic Resistance Genes (ARGs) grouped by antibiotic classes across clinical outcome groups.

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Formula = Abundance ~ “OUT_GROUP”+“BIL_INC_ATB”,“PAT_AGE”+ “IMC”+ “CERCLAGE”+“RCIU”+“DIABET_GESTA”+ “HTA_PRE_ECLAM”+(1|PatientID)
OUT_GROUP: study outcome group(A-D); BIL_INC_ATB: antibiotic exposure during pregnancy; PAT_AGE: maternal age; IMC: body mass index; CERCLAGE: cervical cerclage; RCIU intrauterine growth restriction; DIABET_GESTA gestational diabetes; HTA_PRE_ECLAM: hypertensive disorders of pregnancy including pre-eclampsia.
model = CPLM

Supplementary Table 13

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Supplementary Table 13: Differential abundance of Mobile Genetic Elements (MGEs) across clinical outcome groups.

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Formula = Abundance ~ “OUT_GROUP”+“BIL_INC_ATB”,“PAT_AGE”+ “IMC”+ “CERCLAGE”+“RCIU”+“DIABET_GESTA”+ “HTA_PRE_ECLAM”+(1|PatientID)
OUT_GROUP: study outcome group(A-D); BIL_INC_ATB: antibiotic exposure during pregnancy; PAT_AGE: maternal age; IMC: body mass index; CERCLAGE: cervical cerclage; RCIU intrauterine growth restriction; DIABET_GESTA gestational diabetes; HTA_PRE_ECLAM: hypertensive disorders of pregnancy including pre-eclampsia.
model = CPLM

Supplementary Table 14

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Supplementary Table 14: Differential abundance of Mobile Genetic Elements (MGEs) grouped by MGE family level across clinical outcome groups.

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Formula = Abundance ~ “OUT_GROUP”+“BIL_INC_ATB”,“PAT_AGE”+ “IMC”+ “CERCLAGE”+“RCIU”+“DIABET_GESTA”+ “HTA_PRE_ECLAM”+(1|PatientID)
OUT_GROUP: study outcome group(A-D); BIL_INC_ATB: antibiotic exposure during pregnancy; PAT_AGE: maternal age; IMC: body mass index; CERCLAGE: cervical cerclage; RCIU intrauterine growth restriction; DIABET_GESTA gestational diabetes; HTA_PRE_ECLAM: hypertensive disorders of pregnancy including pre-eclampsia.
model = CPLM